Schwinghammer TL, Juhl RP, Dittert LW, Melethil SK, Kroboth FJ, Chung VS. This is a decision you and your doctor will make Promethazine Injection can cause severe chemical irritation and damage to tissues regardless of the route of administration. Promethazine can cause significant alterations of flare response in intradermal allergen tests if performed within 4 d of patient's receiving promethazine Only 24% of respondents believe FDA should withdraw approval for the IV route of administration of promethazine. preferred route of administration for the injectable form of promethazine is intramuscularly, via a large muscle. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration Safety in Using Promethazine (Phenergan) ©2007 Pennsylvania Patient Safety Authority Page 1 preferred parenteral route of administration, pro-methazine’s product labeling states that it may be given by slow IV push, which is the typical method of administration in most hospitals.8. Dr. Case reports describe inadvertent intra-arterial injection. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration Administration of 12.5 to 25 mg Phenergan by the oral route or by rectal suppository at bedtime will provide sedation in children. Promethazine can cause significant alterations of flare response in intradermal allergen tests if performed within 4 d of patient's receiving promethazine Administering promethazine phenergan route by intravenous or intraarterial routes has been found to result in arterial spasm and, in turn, to impaired circulation and gangrene in specific cases. To reduce the risk of these hazards. Oral route (Tablet;Syrup) Promethazine hydrochloride should not be used in pediatric patients less than 2 years old because of the potential for fatal respiratory depression. preferred routes: im or oral. Although not all of these side effects may occur, if they do occur they may need medical attention Formulated with phenol, promethazine has a pH between 4 and 5.5. Promethazine comes in 25mg tablets and mathematically it would take exactlyI'm not going to tell you because I'm afraid that you or someone that reads these answers is going to try to commit suicide and I already have to many bad things on my conscious, I don't think I can handle anymore.. Talk to your pharmacist for more details.Before using this medication, tell. Do NOT use a concentration > 25 mg/ml intravenously because of the risk of serious tissue injury Side Effects. Although the area under the curve for this metabolite is not route dependent, there is a marked alteration in the shape of the metabolite curve when oral and intravenous data are compared Promethazine is distributed widely throughout bodily tissues and organs. Pre- and Postoperative Use PHENERGAN Injection can cause severe chemical irritation and damage to tissues regardless of the route of administration. Some of its characteristic side effects include dizziness and drowsiness Before Using Prorex – Promethazine (Injection Route, Intravenous Route) In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. It may help with some symptoms associated with the common cold. Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as motion sickness, or before/after surgery).It is also used to treat allergy symptoms such as rash, itching, and runny nose.It may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better Phenergan (promethazine HCl) Tablets and Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pre- and Postoperative Use Distribution by route of exposure: Promethazine is widely distributed in body tissues and has a large apparent volume of distribution following oral and intramuscular administration. The use of Phenergan Elixir is recommended for this age group. Adults usually require 25 to 50 mg for nighttime, presurgical, or obstetrical sedation. Cesar Sturla, National University of Pedro Henriquez Urena Answered Feb. This is a decision you and your doctor will make. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration preferred route of administration for the injectable form of promethazine is intramuscularly, via a large muscle. 12, 2014 33 years experience in Internal Medicine. After taking a sublingual phenergan (promethazine) I have developed two red round sours on my frenulum. Since oral tablets or suppositories are not always desirable for treating nausea, a transdermal gel may be custom-made by. Phenergan (Promethazine HCl) Suppositories, USP are for rectal administration only. I was taught 2cc the max in the deltoid, but would rarely do that much unless there were reasons i had to. Prochlorperazine can cause extra pyramidal effects similar to promethazine: sedation, hypotension and cardiac dysrhythmias including QT prolongation Promethazine transdermal gel (aka Phenergan Gel) is used to treat nausea and vomiting. Most lawsuits will end in a settlement out of court, which always means a private agreement Promethazine may interfere with blood grouping in ABO system and may produce false results with urinary pregnancy tests (Gravindex, false-positive; Prepurex and Dap tests, false-negative). It is available by mouth as a syrup, as a rectal suppository, or by injection into a muscle Common side effects include confusion and sleepiness..